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Exploring the Mechanism of Action of Retatrutide

Retatrutide is a triple-hormone-receptor agonist that activates three receptors involved in appetite regulation and glucose control. The three hormones targeted by retatrutide are glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCG).
GLP-1 Receptor Activation: Retatrutide activates the GLP-1 receptor, crucial in regulating appetite and promoting satiety. The intestines release GLP-1 in response to food consumption and helps reduce food intake by signaling the brain to feel full. By activating the GLP-1 receptor, retatrutide enhances feelings of fullness and reduces hunger.
GIP Receptor Activation: Retatrutide also activates the GIP receptor, which is involved in glucose metabolism. The intestines release GIP in response to food intake, stimulating insulin release from pancreatic beta cells. By activating the GIP receptor, retatrutide promotes insulin secretion, which helps regulate blood sugar levels.
Glucagon Receptor Activation: Retatrutide activates the glucagon receptor, which plays a role in glucose control and energy balance. The pancreas releases glucagon and promotes the breakdown of glycogen stored in the liver, increasing blood sugar levels. By activating the glucagon receptor, retatrutide can help regulate glucagon levels and improve glucose homeostasis.

Retatrutide aims to regulate appetite, increase feelings of fullness, promote insulin secretion, and improve glucose control by targeting these three receptors. This triple agonist mechanism of action makes retatrutide a promising candidate for treating obesity and diabetes.


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