What should be done if the weight loss effect of using semaglutide is not satisfactory?

Who has poor weight loss effect with semaglutide?

Among overweight and obese individuals, over 85% of users can achieve at least 5% weight loss, about 70% can achieve at least 10% weight loss, over half can achieve at least 15% weight loss, about one-third can achieve at least 20% weight loss, and less than 5% of people experience weight gain instead of weight loss. The study also found that Smeaglutide had a significant weight loss effect regardless of age, gender, race, initial weight, BMI, type 2 diabetes and renal function. However, when women, non type 2 diabetes patients and people with lower initial weight use smeglutide, the weight loss effect will be more obvious. It is worth noting that compared with non diabetes patients, type 2 diabetes patients may lose weight less than expected due to a variety of reasons, such as fear of hypoglycemia, overeating, lack of exercise, decreased urine sugar, use of other weight gain drugs, and psychological stress caused by diabetes.

If the effect of using semaglutide for weight loss is not satisfactory, the medication should not be discontinued and should be continued.

The initial dose is 0.25mg, increasing every four weeks until the best effect of 2.4mg can be achieved by the 16th week. By 20 weeks, about 12% of patients had no significant weight loss effect (weight loss<5%), but after persisting in medication until 68 weeks, up to 57% of them successfully lost more than or equal to 5% weight. Most individuals who are initially ineffective can achieve significant weight loss by week 68 as long as they persist with medication. Of course, early response to semaglutide is a good indicator of long-term effectiveness.