Do I need to adjust the small dosage to continue using semaglutide after achieving my ideal weight?

  After effective hypoglycemic and weight loss treatment, most overweight/obese T2DM patients can lose 4% -10% of their initial weight within 4-6 months, but there are individual differences. After the plateau period, weight may rebound, mainly due to fat accumulation. This fluctuation may stem from the "metabolic memory effect" of body components, which means that when weight decreases, the brain will increase appetite and promote energy absorption through feedback regulation, leading to fat accumulation and triggering weight rebound. This rebound is actually a process of "repeatedly losing weight and then gaining weight" . Weight fluctuations can affect health and are associated with the incidence of all-cause mortality, heart failure, cardiovascular death, and cardiovascular events in T2DM patients. 

    Therefore, after achieving ideal body weight with Simeglutide Injection, in order to maintain long-term weight compliance and cardiovascular protection effects, and improve prognosis, it is recommended to use medication for a long time while closely monitoring weight changes to prevent significant fluctuations and avoid blind reduction. Regarding weight management in obese patients, firstly, due to the decrease in GLP-1 activity, discontinuing semaglutide can cause symptoms similar to withdrawal reactions. Next, when patients stop taking medication soon, they need to adapt to the new state and face difficulties such as increased appetite and decreased satisfaction from food. Sudden cessation of medication may also cause troubles such as rising blood sugar, weight gain, and blood pressure.

    Then, from a biological perspective, research has found that in addition to diet, semaglutide can also affect a person's desire to drink alcohol. Once the medication is stopped, the physiological and psychological impulse to drink will return to normal. Furthermore, restoring weight is not more beneficial than maintaining weight. Individuals may experience repeated fluctuations between high and low body weight, which is known as the 'weight cycle', with more cycles indicating greater difficulty in losing weight. That is to say, if sudden discontinuation of medication leads to weight regain, previous efforts may be in vain, and the difficulty of losing weight again in the future will also increase. So, we do not recommend stopping medication at will, but should gradually adjust according to individual circumstances. At the same time, it is important to have a deep understanding and practice healthy lifestyles and dietary habits to better control hunger and satiety, and maintain an ideal weight. GLP-1 is a naturally occurring substance in the human body, and exogenous intake can interfere with its secretion. 

    Therefore, sudden discontinuation of the medication can prevent the body from returning to its original state, and rebound is inevitable. It is recommended to adjust the dosage according to personal circumstances, allowing the body to gradually restore natural secretion, understand one's own needs, optimize lifestyle and dietary structure, so as to maintain a healthy weight in the long run.